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Contraindications
Concurrent use with opioids or other analgesics that suppress respiration.
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Special Precautions
Patient with asthma, hay fever, or urticaria. Hypersensitivity to horses or horse-based products; papaya or papain (North American crotalid antivenin). Not for prophylactic use in asymptomatic patient. Pregnancy and lactation. Monitoring Parameters Monitor the emergence of symptoms of hypersensitivity reactions; resolution of symptoms of envenomation. Monitor respiratory function and oxygenation; urine for hemoglobinuria.
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Adverse Reactions
Significant: Hypersensitivity reactions (e.g. anaphylaxis), delayed serum sickness.
Cardiac disorders: Chest pain.
Gastrointestinal disorders: Nausea, vomiting, abdominal pain, diarrhoea.
General disorders and administration site conditions: Local injection site reactions, pyrexia, chills.
Musculoskeletal and connective tissue disorders: Myalgia.
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Rash, urticaria.
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Drug Interactions
May prolong and potentiate the severity of acute anaphylaxis with β-blockers.
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CIMS Class
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ATC Classification
J06AA03 - snake venom antiserum ; Belongs to the class of immune sera. Used in the treatment of acute infectious diseases caused by toxigenic strains.
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